Type : | Académique |
Statut : | Ouvert |
Phase : | II |
Étape du traitement : | Thérapie ciblée |
Date d'ouverture : | 06/11/2019 |
Date clôture : | 15/10/2025 |
Promoteur : | Jules Bordet Institute |
Progression du cancer: | Loco-régional |
Neo-CheckRay is a multicenter, open-label phase II study that randomizes luminal B breast cancer subjects candidate for neo-adjuvant chemotherapy in a 1:1:1 ratio in 3 arms:
- the combination of weekly paclitaxel followed by dose-dense doxorubicin-cyclophosphamide (ddAC) and pre-operative radiation therapy (boost dose) on the primary tumour
- arm 1 with the addition of the anti-PD-L1 antibody durvalumab
- arm 2 with the addition of the anti-CD73 antibody oleclumab The primary tumour will be excised 2-6 weeks after completion of ddAC. A safety run-in is planned for the 6 first subjects before starting the randomized phase II trial. Those 6 subjects will receive the treatment given in Arm 3.
- Cancer du sein
- HER2
- ER
- Tumeur maligne du sein - Cim10 : C50